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Imaging Follow-up of Low-Risk
Incidental Pancreas and Kidney
Findings: Effects of Patient Age
and Comorbidity on Projected Life
Expectancy
Autor: Tiana J. Raphel, BA; Davis T. Weaver, BS; Lincoln L. Berland, MD; Brian R. Herts, MD; Alec J. Megibow, MD, MPH; Amy B. Knudsen, PhD; Pari V. Pandharipande, MD, MPH
Objetivo Describir la técnica y resultados en cuanto a la mejoría del dolor y
complicaciones al realizar este procedimiento mediante guía por tomografía
computada.
Materiales y Métodos Estudio observacional descriptivo de una serie de 108
pacientes a quienes se les realizó vertebroplastia percutánea guiada por tomografía
computada realizadas en dos hospitales universitarios, entre mayo 2007 y mayo 2017.
Todos los procedimientos se realizaron de forma ambulatoria con anestesia local y se
valoró el dolor mediante la escala visual análoga.
Resultados Se realizaron 125 vertebroplastias, en el 87,9% de los pacientes (n ¼ 95)
se realizó el procedimiento en un cuerpo vertebral, en el 8,3% (n ¼ 9) y 3,7% (n ¼ 4) de
los pacientes se cementaron 2 y 3 vertebras respectivamente. El rango de dolor según
la escala visual análoga (EVA) previo al tratamiento varió entre 5 y 10, donde un 94%
(n ¼ 102) de los pacientes manifestaban una intensidad 10/10. En el postratamiento el
rango de dolor varió entre 0 a 7 donde el 98% de la población reportó un valor menor o
igual a 3. Se presentaron 3 complicaciones: tromboembolismo pulmonar por metilmetacrilato,
extravasación al plexo de Batson y extravasación al espacio interdiscal,
cada una en tres pacientes diferentes.
Conclusión La vertebroplastia percutánea guiada por TC ofrece una indiscutible
mejora inmediata del dolor en pacientes con fractura de uno o más cuerpos
vertebrales, con una baja tasa de complicaciones.
Palabras clave: vertebroplastia, tomografía
computada, multidetector, fractura vertebra.
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Purpose: To determine the effects of patient age and comorbidity
level on life expectancy (LE) benefits associated with
imaging follow-up of Bosniak IIF renal cysts and pancreatic
side-branch (SB) intraductal papillary mucinous neoplasms
(IPMNs).
Materials and Methods: A decision-analytic Markov model to evaluate LE benefits
was developed. Hypothetical cohorts with varied age (60–
80 years) and comorbidities (none, mild, moderate, or
severe) were evaluated. For each finding, LE projections
from two strategies were compared: imaging follow-up
and no imaging follow-up. Under follow-up, it was assumed
that cancers associated with the incidental finding
were successfully treated before they spread. For patients
without follow-up, mortality risks from Bosniak IIF cysts
(renal cell carcinoma) and SBIPMNs (pancreatic ductal
adenocarcinoma) were incorporated. Model assumptions
and parameter uncertainty were evaluated in sensitivity
analysis.
Results: In the youngest, healthiest cohorts (age, 60 years; no comorbidities),
projected LE benefits from follow-up were
as follows: Bosniak IIF cyst, 6.5 months (women) and 5.8
months (men); SBIPMN, 6.4 months (women) and 5.3
months (men). Follow-up of Bosniak IIF cysts in 60-yearold
women with severe comorbidities yielded a LE benefit
of 3.9 months; in 80-year-old women with no comorbidities,
the benefit was 2.8 months, and with severe comorbidities
the benefit was 1.5 months. Similar trends were
observed in men and for SBIPMN. Results were sensitive
to the performance of follow-up for cancer detection;
malignancy risks; and stage at presentation of malignant,
unfollowed Bosniak IIF cysts.
Conclusion: With progression of age and comorbidity level, follow-up
of low-risk incidental findings yields increasingly limited
benefits for patients.
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