 |
Administración de medios de contraste. ¿Existe riesgo
de daño renal agudo?
Autores: M.D. Ferrer Puchol a,∗
, P. Montesinos Garcíaa
, M. Forment Navarroa
,
E. Sanz Rodrigo
, E. Blanco Pérez y E. Taberner López
Español: |
|
| |
|
Objetivo:
Conocer si la administración intravenosa de contraste yodado en la tomografía computarizada (TC) se asocia a un aumento en los niveles de creatinina y de dano˜ renal agudo.
Material y métodos:
Estudio de cohortes retrospectivo. Incluye todos los pacientes que acudieron al servicio de urgencias del 2010 al 2015 y que presentaban una creatinina basal (C1) y otra
24-72 horas después (C2). El Comité de Ética y de Investigación aprobó el estudio. Criterios
de exclusión: paciente menor de 18 anos, ˜ creatinina ≤ 0,4 mg/dl, ≥4,0 mg/dl y administración de contraste en los últimos 6 meses. Al servicio de urgencias acudieron una media de
105.435,6 pacientes/ano. ˜ Tres grupos de pacientes: 1) TC con contraste (6.642), 2) TC sin
contraste (6.193,3) y 3) Sin TC (33.802). Se usaron los criterios de Acute Kidney Injury Network
(AKI) y nefropatía aguda por contraste (NAC). Se realizó estudio estadístico bivariante y de
regresión logística con el programa (Stata15).
Resultados:
Se analizaron 52.411 pacientes; depurando datos: 46.637. Edad media: 67,95 anos. ˜
Valor de C1: media 1,16 mg/dl (DE: 0,61) y de C2: 1,14 mg/dl (DE: 0,66). Con criterios AKI y
NAC: la realización de TC con contraste no se asocia a una mayor probabilidad de desarrollar
nefropatía (odds ratio [OR]: 0,90, intervalo de confianza [IC]: 0,83-0,99 y OR 0,89, IC: 0,81-0,98,
respectivamente). El estudio ‘‘propensity score matching’’, usando ambos criterios (AKI + NAC),
obtuvo una OR de 0,80 y una IC de 0,77-0,84. Pacientes con filtrado glomerular inferior a
30 ml/min no asociaron incremento del dano˜ renal (OR: 0,66, IC: 0,47-0,91).
Conclusión: La administración de contraste intravenoso, en el grupo de pacientes estudiados,
no está asociada a un aumento del dano˜ renal agudo
|
|
English: |
|
| |
|
Objectives:
To determine whether the intravenous administration of iodinated contrast material
for computed tomography (CT) is associated with an increase in creatinine levels and acute
kidney injury.
Materials and methods:
This retrospective cohort study included all patients who presented at
the emergency department between 2010 and 2015 with baseline creatinine measurement (C1)
and follow-up creatinine measurement (C2) between 24 and 72 hours later. The clinical research
ethics committee approved the study. The exclusion criteria were age < 18 years, creatinine ≤
0.4 mg/dl or ≥4.0 mg/dl, and the administration of contrast media within the previous 6 months.
The mean number of patients presenting at the emergency department was 105,435.6 per year.
Patients who met the inclusion criteria were classified into three groups: those who underwent
contrast-enhanced CT (n = 6,642), those who underwent noncontrast CT (n = 6,193), and those
who did not undergo CT (n = 33,802). We used the Acute Kidney Injury Network’s (AKIN) and
the Contrast-induced Nephropathy Consensus Working Panel’s (CIN) criteria. Statistical analyses included bivariate statistics and logistic regression. Stata 15 was used for all statistical analyses.
Results:
We analyzed 52,411 patients; after data cleansing: 46,637; mean age: 67.95 years; C1:
mean 1.16 mg/dl (SD: 0.61); C2: 1.14 mg/dl (SD: 0.66). With AKIN and CIN criteria: contrastenhanced CT was not associated with a greater probability of developing nephropathy (odds
ratio [OR: 0.90; 95% CI: 0.83---0.99] and [OR 0.89, 95% CI: 0.81---0.98], respectively). The propensity score matching study using both sets of criteria (AKIN + CIN) yielded OR 0.80 [95% CI:
0.77---0.84]. Glomerular filtration rates less than 30 ml/min were not associated with increased
kidney damage [OR: 0.66, 95% CI: 0.47---0.91].
Conclusion: The administration of intravenous contrast material in the patients studied is not
associated with increased acute kidney injury.
|
|
|